The TOR signaling cascade regulates gene expression in response to nutrients.
Identifieur interne : 001A47 ( Main/Exploration ); précédent : 001A46; suivant : 001A48The TOR signaling cascade regulates gene expression in response to nutrients.
Auteurs : M E Cardenas [États-Unis] ; N S Cutler ; M C Lorenz ; C J Di Como ; J. HeitmanSource :
- Genes & development [ 0890-9369 ] ; 1999.
Descripteurs français
- KwdFr :
- Azote (métabolisme), Cycloheximide (pharmacologie), Génotype (MeSH), Humains (MeSH), Milieux de culture (MeSH), Mitochondries (métabolisme), Protéines de Drosophila (MeSH), Protéines fongiques (génétique), Protéines ribosomiques (génétique), Récepteurs à activité tyrosine kinase (métabolisme), Régulation de l'expression des gènes fongiques (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (physiologie), Sirolimus (pharmacologie), Transcription génétique (effets des médicaments et des substances chimiques), Transduction du signal (physiologie).
- MESH :
- effets des médicaments et des substances chimiques : Régulation de l'expression des gènes fongiques, Saccharomyces cerevisiae, Transcription génétique.
- génétique : Protéines fongiques, Protéines ribosomiques, Saccharomyces cerevisiae.
- métabolisme : Azote, Mitochondries, Récepteurs à activité tyrosine kinase.
- pharmacologie : Cycloheximide, Sirolimus.
- physiologie : Saccharomyces cerevisiae, Transduction du signal.
- Génotype, Humains, Milieux de culture, Protéines de Drosophila.
English descriptors
- KwdEn :
- Culture Media (MeSH), Cycloheximide (pharmacology), Drosophila Proteins (MeSH), Fungal Proteins (genetics), Gene Expression Regulation, Fungal (drug effects), Genotype (MeSH), Humans (MeSH), Mitochondria (metabolism), Nitrogen (metabolism), Receptor Protein-Tyrosine Kinases (metabolism), Ribosomal Proteins (genetics), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (physiology), Signal Transduction (physiology), Sirolimus (pharmacology), Transcription, Genetic (drug effects).
- MESH :
- chemical , genetics : Fungal Proteins, Ribosomal Proteins.
- chemical , metabolism : Nitrogen, Receptor Protein-Tyrosine Kinases.
- chemical , pharmacology : Cycloheximide, Sirolimus.
- chemical : Culture Media, Drosophila Proteins.
- drug effects : Gene Expression Regulation, Fungal, Saccharomyces cerevisiae, Transcription, Genetic.
- genetics : Saccharomyces cerevisiae.
- metabolism : Mitochondria.
- physiology : Saccharomyces cerevisiae, Signal Transduction.
- Genotype, Humans.
Abstract
Rapamycin inhibits the TOR kinases, which regulate cell proliferation and mRNA translation and are conserved from yeast to man. The TOR kinases also regulate responses to nutrients, including sporulation, autophagy, mating, and ribosome biogenesis. We have analyzed gene expression in yeast cells exposed to rapamycin using arrays representing the whole yeast genome. TOR inhibition by rapamycin induces expression of nitrogen source utilization genes controlled by the Ure2 repressor and the transcriptional regulator Gln3, and globally represses ribosomal protein expression. gln3 mutations were found to confer rapamycin resistance, whereas ure2 mutations confer rapamycin hypersensitivity, even in cells expressing dominant rapamycin-resistant TOR mutants. We find that Ure2 is a phosphoprotein in vivo that is rapidly dephosphorylated in response to rapamycin or nitrogen limitation. In summary, our results reveal that the TOR cascade plays a prominent role in regulating transcription in response to nutrients in addition to its known roles in regulating translation, ribosome biogenesis, and amino acid permease stability.
DOI: 10.1101/gad.13.24.3271
PubMed: 10617575
PubMed Central: PMC317202
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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The TOR kinases also regulate responses to nutrients, including sporulation, autophagy, mating, and ribosome biogenesis. We have analyzed gene expression in yeast cells exposed to rapamycin using arrays representing the whole yeast genome. TOR inhibition by rapamycin induces expression of nitrogen source utilization genes controlled by the Ure2 repressor and the transcriptional regulator Gln3, and globally represses ribosomal protein expression. gln3 mutations were found to confer rapamycin resistance, whereas ure2 mutations confer rapamycin hypersensitivity, even in cells expressing dominant rapamycin-resistant TOR mutants. We find that Ure2 is a phosphoprotein in vivo that is rapidly dephosphorylated in response to rapamycin or nitrogen limitation. In summary, our results reveal that the TOR cascade plays a prominent role in regulating transcription in response to nutrients in addition to its known roles in regulating translation, ribosome biogenesis, and amino acid permease stability.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10617575</PMID><DateCompleted><Year>2000</Year><Month>01</Month><Day>27</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0890-9369</ISSN><JournalIssue CitedMedium="Print"><Volume>13</Volume><Issue>24</Issue><PubDate><Year>1999</Year><Month>Dec</Month><Day>15</Day></PubDate></JournalIssue><Title>Genes & development</Title><ISOAbbreviation>Genes Dev</ISOAbbreviation></Journal><ArticleTitle>The TOR signaling cascade regulates gene expression in response to nutrients.</ArticleTitle><Pagination><MedlinePgn>3271-9</MedlinePgn></Pagination><Abstract><AbstractText>Rapamycin inhibits the TOR kinases, which regulate cell proliferation and mRNA translation and are conserved from yeast to man. The TOR kinases also regulate responses to nutrients, including sporulation, autophagy, mating, and ribosome biogenesis. We have analyzed gene expression in yeast cells exposed to rapamycin using arrays representing the whole yeast genome. TOR inhibition by rapamycin induces expression of nitrogen source utilization genes controlled by the Ure2 repressor and the transcriptional regulator Gln3, and globally represses ribosomal protein expression. gln3 mutations were found to confer rapamycin resistance, whereas ure2 mutations confer rapamycin hypersensitivity, even in cells expressing dominant rapamycin-resistant TOR mutants. We find that Ure2 is a phosphoprotein in vivo that is rapidly dephosphorylated in response to rapamycin or nitrogen limitation. In summary, our results reveal that the TOR cascade plays a prominent role in regulating transcription in response to nutrients in addition to its known roles in regulating translation, ribosome biogenesis, and amino acid permease stability.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cardenas</LastName><ForeName>M E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Departments of Genetics, Duke University Medical Center, Durham, North Carolina 27710 USA. carde004@mc.duke.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cutler</LastName><ForeName>N S</ForeName><Initials>NS</Initials></Author><Author ValidYN="Y"><LastName>Lorenz</LastName><ForeName>M C</ForeName><Initials>MC</Initials></Author><Author ValidYN="Y"><LastName>Di Como</LastName><ForeName>C J</ForeName><Initials>CJ</Initials></Author><Author 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